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Roles of long non-coding RNAs in cervical cancer.
Life Sciences ( IF 5.2 ) Pub Date : 2020-06-17 , DOI: 10.1016/j.lfs.2020.117981
Fangzhen Luo 1 , Yating Wen 1 , Hui Zhou 2 , Zhongyu Li 1
Affiliation  

Cervical cancer (CC) is regarded as the second serious threat to women's health worldwide; it's associated with certain viruses that are transmitted through sexual intercourse. Therefore, the pathogenesis of CC remains to be studied. The identified long non-coding RNAs (lncRNAs) as a key genomic product were found to be commonly dysregulated in CC and to exert significant effects in the initiation, migration, invasion and therapeutic response of CC. Therefore lncRNAs may be used as tumor suppressor genes or oncogenes to interact with DNA, RNA or proteins for the regulation of gene expression and cell signaling pathways. The relationship between single lncRNA and CC has been discovered. However, full-scale reviews on the lncRNAs function in CC are deficiency. In this review, we describe the recent reports on the dysregulated patterns regulation of lncRNAs in CC. We also conclude the recent advances on biologic functions and molecular regulation mechanism and potential clinical application of lncRNAs in CC.



中文翻译:

长非编码RNA在宫颈癌中的作用。

宫颈癌(CC)被认为是全世界女性健康的第二大严重威胁;它与通过性交传播的某些病毒有关。因此,CC的发病机制仍有待研究。发现已鉴定为关键基因组产物的长非编码RNA(lncRNA)通常在CC中失调,并在CC的起始,迁移,侵袭和治疗反应中发挥重要作用。因此,lncRNA可用作肿瘤抑制基因或癌基因,与DNA,RNA或蛋白质相互作用,以调节基因表达和细胞信号通路。已经发现单个lncRNA和CC之间的关系。但是,有关CC中lncRNAs功能的全面综述尚不足。在这篇评论中 我们描述了有关CC中lncRNA的模式调节失调的最新报道。我们还总结了lncRNA在CC中的生物学功能和分子调控机制的最新进展以及潜在的临床应用。

更新日期:2020-07-02
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