Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation.

中文翻译：

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细胞重编程与衰老和再生中的衰老之间的串扰。

衰老与再生能力下降和慢性病风险增加有关。现在有令人信服的证据表明老化过程是可逆的。除代谢修饰和系统性因素外，衰老消除和细胞重编程均显示出对组织再生和年轻化的有益作用。在这里，我们审查有关细胞衰老和重编程之间相互作用的最新研究。我们讨论了这两种策略如何影响老化过程，以及将它们组合以实现更有效的再生和复兴的可能性。