Evodiae Fructus (EF), the dried nearly mature scented fruit of Tetradium ruticarpum (A.Juss.) T.G.Hartley, was typically used to treat headache, abdominal pain, hernias, and menorrhagia for thousands of years. It had been reported to be a mild toxic herb through metabolic activation mainly by CYP3A but was barely explained from pharmacokinetic interaction. The aim of the study was to investigate the role of CYP3A inducer/inhibitor in pharmacokinetics of five alkaloids (evodiamine (EVOD), rutaecarpine (RUTA), 1-methyl-2-undecyl-4(1H)-quinolone (MUDQ), 1-methyl-2-nonyl-4(1H)-quinolone (MNNQ) and evocarpine (EVOC)) associated with hepatotoxicity of EF in Sprague Dawley (SD) rats. The results demonstrated that the metabolism of the five alkaloids of EF were inhibited in presence of CYP3A inhibitor whereas the metabolism of the five alkaloids of EF were promoted in presence of CYP3A inducer. Therefore, the dose is required attention when EF is taken in conjunction with CYP3A inducer as there is an enhancement in drug metabolism, which might lead to toxicity.

山茱T（Tetradium ruticarpum）（A.Juss。）TGHartley几乎干燥的成熟香味果，常被用于治疗头痛，腹痛，疝气和月经过多。据报道，它是一种主要通过CYP3A通过代谢激活而引起的轻度毒性草药，但从药代动力学相互作用几乎没有得到解释。这项研究的目的是研究CYP3A诱导剂/抑制剂在5种生物碱（evodiamine（EVOD），rutaecarpine（RUTA），1-甲基-2-十一烷基-4（1 H）-喹诺酮（MUDQ）， 1-甲基-2-壬基-4（1 H）-喹诺酮（MNNQ）和evocarpine（EVOC））与EF对Sprague Dawley（SD）大鼠的肝毒性有关。结果表明，在CYP3A抑制剂存在下，EF的5种生物碱的代谢受到抑制，而在CYP3A诱导剂存在下，EF的5种生物碱的代谢得到促进。因此，当EF与CYP3A诱导剂联用时，需要注意剂量，因为药物代谢会增强，这可能导致毒性。