Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2020-06-17 , DOI: 10.1016/j.bioorg.2020.104018 Zi-Jun Ye 1 , Xiao-Ai He 1 , Jian-Ping Wu 2 , Jing Li 2 , Xi-Wen Chang 2 , Jie Tan 2 , Wen-Yan Lv 2 , Hui Zhu 2 , Hui-Hui Sun 2 , Wen-Xuan Wang 2 , Zu-Hui Chen 3 , Gang-Zhi Zhu 1 , Kang-Ping Xu 2
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Eight new prenylflavonol glycosides (1–8), along with five known analogues (9–13) were isolated from the n-butanol extract of the dried leaves of Cyclocarya paliurus (family Juglandaceae) for the first time. The structures of these compounds were characterized by comprehensive analysis of 1D, 2D NMR, HRESIMS, UV data and acid hydrolysis. In bioassay, all these thirteen prenylflavonol glycosides exhibited inhibitory effects on xanthine oxidase (XOD) activity. Especially compounds 2 and 7, showed outstanding IC50 values of 31.81 ± 2.20 and 29.71 ± 3.69 μM, respectively.
中文翻译：
具有黄嘌呤氧化酶抑制活性的新异戊烯黄酮糖苷，来自Cyclocarya paliurus的叶子。
八个新prenylflavonol甙（1 - 8）中，用5个已知类似物（沿9 - 13）从分离Ñ的干叶提取物丁醇青钱柳（胡桃科家族），用于在第一时间。这些化合物的结构通过对1D，2D NMR，HRESIMS，UV数据和酸水解的综合分析来表征。在生物测定中，所有这十三种异戊烯基黄酮醇苷均对黄嘌呤氧化酶（XOD）活性具有抑制作用。特别是化合物2和7分别显示出出色的IC 50值31.81±2.20和29.71±3.69μM。
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