Thionation of adatanserin hydrochloride (2) with Lawesson's reagent in toluene/triethylamine afforded novel compound, (3r,5r,7r)-N-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)adamantane-1-carbothioamide (thioadatanserin, 3) in 84–90% isolated yield. Thioadatanserin underwent a tandem double alkylation with methyl iodide and benzyl bromide in NaH/THF to produce novel dialkylated products 6 and 7 respectively. The single X-ray crystal structure of 7 was determined to be 1-(2-((E- ((3r,5r,7r)-adamantan-1-yl)benzylthio)methylene)amino)ethyl)-1-benzyl-4- (pyrimidin-2-yl)piperazin-1-ium bromide showing that the piperazine ring adopts a chair-like configuration that is not co-planar with the pyrimidine ring. Thioadatanserin emerged as a dual potent partial agonist with activity against 5-HTR_1A (EC₅₀ 6.7 nM) and antagonist activity against 5-HTR_2A (IC₅₀ 62.3 nM) and was selective over 5-HTR_2C receptor (IC₅₀ > 3333 nM) in the PathHunter® β-arrestin assays.

用Lawesson's试剂在甲苯/三乙胺中亚铁钠盐酸盐（2）进行亚硫酰化，得到新化合物（3r，5r，7r）-N-（2-（4-（嘧啶-2-基）哌嗪-1-基）乙基）金刚烷-1-碳硫酰胺（thioadatanserin，3）的分离产率为84–90％。硫代丹参素在NaH / THF中用甲基碘和苄基溴进行串联双烷基化反应，分别制得新的二烷基化产物6和7。X射线单晶晶体结构7确定为1-（2-（（（E-（（3r，5r，7r）-金刚烷-1-基）苄硫基）亚甲基）氨基）乙基）-1-苄基-4-（嘧啶-2-基）哌嗪-1-溴化铵表明，哌嗪环采用与嘧啶环不共面的椅子状构型。硫丹坦丝素是一种双重有效的部分激动剂，对5-HTR _1A（EC ₅₀ 6.7 nM）具有活性，对5-HTR _2A具有拮抗剂活性（IC ₅₀ 62.3 nM），对5-HTR _2C受体具有选择性（IC ₅₀  > 3333 nM ）在PathHunter®β-arrestin分析中。