Abstract— Structure and spatial relationships of microglia and tanycytes in the mediobasal hypothalamus in early postnatal development and during aging were examined. Brain sections of Wistar rats at postnatal days 7, 14, and 30 and at the age of 4–5 (adult) and 20 months (aged) ( n = 3 for each time point) were studied using immunohistochemical methods. Different types of microglia were defined according to localization, morphological and functional features, and spatial relationships with tanycytes. Age-related changes in microglia activity were demonstrated in the area studied. The data will allow for revealing the role of microglia and tanycytes in the formation of barrier structures in the mediobasal hypothalamus and the age-related specifics of the central neuroimmunoendocrine regulations.

中文翻译：

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出生后早期发育和衰老过程中脑漏斗部的小胶质细胞和绦虫

摘要：研究了出生后早期发育和衰老过程中下丘脑中基底层小胶质细胞和长核细胞的结构和空间关系。使用免疫组织化学方法研究了出生后第 7、14 和 30 天以及 4-5 岁（成年）和 20 个月（每个时间点 n = 3）的 Wistar 大鼠的脑切片。根据定位、形态和功能特征以及与长细胞的空间关系定义了不同类型的小胶质细胞。在所研究的区域中证明了与年龄相关的小胶质细胞活动的变化。这些数据将有助于揭示小胶质细胞和长核细胞在下丘脑中基底层屏障结构形成中的作用以及中枢神经免疫内分泌调节的年龄相关细节。