Cork-modified graphite electrodes were used to develop a simple and selective sensor for the simultaneous determination of paracetamol (PAR) and caffeine (CAF). The sensor was fabricated on raw cork (RAC) and regranulated cork (RGC). When modified with RAC, graphite (GrRAC) displayed an improvement in voltammetric responses for PAR and CAF compared to the sensor modified with RGC (GrRGC). By applying differential pulse voltammetry (DPV) in an acidic medium with the GrRAC sensor, it was possible to simultaneously determine the concentrations of PAR and CAR (ranging from 0 to 50 μM), with limits of detection of 8.36 and 12.25 μM, respectively. The fabricated electrochemical sensor was able to individually and simultaneously detect PAR and CAF in different samples, confirming that the proposed sensor is a practical and effective tool for determining these pharmaceuticals in dosage forms and synthetic urine. Moreover, GrRAC and GrRGC possessed several advantages compared with current methods of detection, including very low detection limits, high sensitivity, long-term stability, and excellent reproducibility.

软木修饰的石墨电极用于开发一种简单而选择性的传感器，用于同时测定扑热息痛（PAR）和咖啡因（CAF）。该传感器是在原木塞（RAC）和再生软木塞（RGC）上制造的。与RGC修饰的传感器相比，当用RAC修饰时，石墨（GrRAC）对PAR和CAF的伏安响应有所改善。通过使用GrRAC传感器在酸性介质中应用差分脉冲伏安法（DPV），可以同时测定PAR和CAR的浓度（0至50μM），检出限分别为8.36和12.25μM。制成的电化学传感器能够分别同时检测不同样品中的PAR和CAF，确认所建议的传感器是确定剂型和合成尿中这些药物的实用有效工具。而且，与当前的检测方法相比，GrRAC和GrRGC具有许多优势，包括非常低的检测限，高灵敏度，长期稳定性和出色的重现性。