Abstract

It was shown that the level of nitric oxide metabolites in the blood plasma of people with essential arterial hypertension (EAH) is significantly higher than that of healthy donors. This pattern did not depend on the stage of the disease, but on the age of the subjects, as well as on whether patients with cardio-selective β-adrenoreceptor blockers take them or not. It was established that an increase in the level of nitrites and nitrates in the blood of patients with EAH was accompanied by an increase in the level of transcripts of the NOS2 gene in the peripheral blood leukocytes (PBL), while the mRNA content of the NOS3 gene in the PBL patients was slightly lower than that of healthy donors.

中文翻译：

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原发性高血压患者一氧化氮代谢物水平及NOS2和NOS3基因转录本

摘要

结果表明，患有原发性高血压的人血浆中的一氧化氮代谢产物水平显着高于健康捐献者。这种模式不取决于疾病的阶段，而是取决于受试者的年龄，以及具有心脏选择性β-肾上腺素受体阻滞剂的患者是否服用。已经确定，EAH患者血液中亚硝酸盐和硝酸盐水平的增加伴随着外周血白细胞（PBL）中NOS2基因的转录水平的升高，而NOS3的mRNA含量升高PBL患者中的基因略低于健康供体。