A facile and straightforward synthesis of unsymmetrically substituted N-aryl oxalamides from 2,2′-biphenyldiamines, 2-chloroacetic acid derivatives, elemental sulfur, and water has been developed. This protocol is distinguished by efficiency in water under metal-free conditions for N-aryl oxalamides bearing a side-chain NH₂-group; it can be adapted for scale-up synthesis. The scope and limitations of this transformation have been investigated.

中文翻译：

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通过级联的硫酰胺化/环缩合和水解反应进行硫介导的不对称取代的N-芳基草酰胺的合成。

已开发了一种由2,2'-联苯二胺，2-氯乙酸衍生物，元素硫和水轻松快速地合成不对称取代的N-芳基草酰胺的方法。该方案的特点是在无金属条件下水中带有侧链NH _2-基团的N-芳基草酰胺的效率。它可以适用于按比例放大的合成。已经研究了这种转变的范围和局限性。