The molecular design of and challenges relating to sensitizers for cancer sonodynamic therapy,Materials Chemistry Frontiers

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The molecular design of and challenges relating to sensitizers for cancer sonodynamic therapy
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2020-06-16 , DOI: 10.1039/d0qm00232a
Yiming Zhou _{1,

2,

3,

4,

5} , Mengxuan Wang _{1,

2,

3,

4,

5} , Zhifei Dai _{1,

2,

3,

4,

5}

Affiliation

Sonodynamic therapy is a promising non-invasive treatment approach against malignant tumors. It is believed that sonodynamic therapy is advantageous over conventional photodynamic therapy due to its better penetration abilities. However, the efficacy of sonodynamic therapy is limited by the poor reactive oxygen species generation abilities of current sonosensitizers. To fulfill the unreleased potential of sonodynamic therapy, it is reasonable to optimize the properties of the sonosensitizers according to the basic mechanism of sonodynamic therapy. Here, in this review, the most recent research progress relating to the mechanism of sonodynamic therapy will be emphasized and a series of possible principles for the design of effective sonosensitizers will be proposed. Further challenges relating to the clinical translation of sonodynamic therapy will also be discussed to give a clear picture of the problems that must be overcome.

中文翻译：

癌症声动力学治疗敏化剂的分子设计和相关挑战

声动力疗法是一种针对恶性肿瘤的有前途的非侵入性治疗方法。可以认为，声动力疗法由于其更好的穿透能力而优于常规的光动力疗法。然而，声动力疗法的功效受到当前声敏剂不良的活性氧种类生成能力的限制。为了满足声波动力疗法的未释放潜力，根据声波动力疗法的基本机理优化声波增敏剂的性能是合理的。在本文中，本文将重点介绍与声动力疗法机理相关的最新研究进展，并提出一系列可能的原理，以设计有效的声敏剂。

更新日期：2020-07-30

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