Background The use of natural products is an essential way to new pharmaceutical leads for the discovery and development of new drugs to treat diseases. Propolis (Pro) is a natural resinous product produced by honey bees. It has a strong cytoprotective effect against various exogenous toxic agents. The current study was designed to evaluate the possible protective effect of propolis against the toxicity of aluminum chloride (AlCl 3 ) on hepatorenal structure and function in male white albino rats. Methods Thirty mature males of albino rat, Rattus rattus , weighing about 80-90g were divided into five groups contained 6 rats each. The first group acts as a control (received only saline solution); the second group (Al) had given orally 40 mg/kg b.w. of AlC1 3 , the third group (Pro) had administrated orally 150 mg/kg b.w. of propolis and the fourth group (Al+Pro) had given 40 mg/kg b.w. of AlCl 3 in the morning and 150 mg/kg b.w. of propolis in the evening. These four groups had given the treatments for two months. The fifth group (Al-Pro) had given 40 mg/kg b.w. of AlC1 3 chloride for one month then had given 40 mg/kg b.w. of AlCl 3 combined with 150 mg/kg b.w. of propolis for another month. Results The AlCl 3 -treated group showed a significant increase in the activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), acid phosphatase (AP), and lactate dehydrogenase (LDH) in the plasma. Also, glucose, total protein, albumin, creatinine, uric acid, urea, cholesterol, and triglycerides in the plasma were significantly increased. The histological examination for the liver and kidney sections revealed marked histopathological alternations. The treatment with propolis combined with AlCl 3 improved the previous mentioned biochemical and histological alterations induced by AlCl3. Conclusion It can be concluded that the combination of propolis with AlCl 3 alleviated the toxic effects of AlCl 3 . The propolis has protective influences on the hepatorenal structure and function and could be able to resist AlCl 3 intoxication.

中文翻译：

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蜂胶对氯化铝致白化大鼠肝肾毒性的保护作用

背景 天然产物的使用是发现和开发治疗疾病的新药的新药学先导的重要途径。蜂胶 (Pro) 是一种由蜜蜂生产的天然树脂产品。它对各种外源性毒剂具有很强的细胞保护作用。目前的研究旨在评估蜂胶对氯化铝 (AlCl 3 ) 对雄性白色白化大鼠肝肾结构和功能的毒性的可能保护作用。方法将成熟雄性白化大鼠30只，体重约80-90g，分为5组，每组6只。第一组作为对照（仅接受盐水溶液）；第二组 (Al) 口服 40 mg/kg bw AlCl 3 ，第三组 (Pro) 口服 150 mg/kg bw 蜂胶和第四组 (Al+Pro) 在早上给予 40 毫克/公斤体重的 AlCl 3 和在晚上给予 150 毫克/公斤体重的蜂胶。这四组已经进行了两个月的治疗。第五组 (Al-Pro) 给予 40 毫克/千克体重的 AlCl 3 氯化物一个月，然后给予 40 毫克/千克体重的 AlCl 3 结合 150 毫克/千克体重的蜂胶一个月。结果AlCl 3 处理组血浆中天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、酸性磷酸酶(AP)和乳酸脱氢酶(LDH)活性显着增加。此外，血浆中的葡萄糖、总蛋白、白蛋白、肌酐、尿酸、尿素、胆固醇和甘油三酯显着增加。肝脏和肾脏切片的组织学检查显示显着的组织病理学改变。蜂胶与 AlCl 3 组合处理改善了前面提到的由 AlCl 3 诱导的生化和组织学改变。结论可以得出结论，蜂胶与AlCl 3 的组合减轻了AlCl 3 的毒性作用。蜂胶对肝肾结构和功能具有保护作用，并能抵抗AlCl 3 中毒。