Hot stage microscopy (HSM) is a thermal analysis technique that combines the best properties of thermal analysis and microscopy. HSM is rapidly gaining interest in pharmaceuticals as well as in other fields as a regular characterization technique. In pharmaceuticals HSM is used to support differential scanning calorimetry (DSC) and thermo-gravimetric analysis (TGA) observations and to detect small changes in the sample that may be missed by DSC and TGA during a thermal experiment. Study of various physical and chemical properties such sample morphology, crystalline nature, polymorphism, desolvation, miscibility, melting, solid state transitions and incompatibility between various pharmaceutical compounds can be carried out using HSM. HSM is also widely used to screen cocrystals, excipients and polymers for solid dispersions. With the advancements in research methodologies, it is now possible to use HSM in conjunction with other characterization techniques such as Fourier transform infrared spectroscopy (FTIR), DSC, Raman spectroscopy, scanning electron microscopy (SEM) which may have additional benefits over traditional characterization techniques for rapid and comprehensive solid state characterization.

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热台显微镜及其在药物表征中的应用

热台显微镜 (HSM) 是一种热分析技术，它结合了热分析和显微镜的最佳特性。HSM 作为一种常规表征技术，正迅速引起人们对药物以及其他领域的兴趣。在制药领域，HSM 用于支持差示扫描量热法 (DSC) 和热重分析 (TGA) 观察，并检测样品中可能在热实验过程中被 DSC 和 TGA 遗漏的微小变化。可以使用 HSM 研究各种物理和化学特性，例如样品形态、结晶性质、多晶型、去溶剂化、混溶性、熔化、固态转变和各种药物化合物之间的不相容性。HSM 还广泛用于筛选固体分散体的共晶、赋形剂和聚合物。