Streptococcus pneumoniae causes serious infections worldwide. The aim of this study was to determine the molecular characteristic, antibiotic resistance pattern and capsular types of invasive S. pneumoniae in Tehran, Iran. Of the 44 pneumococcal invasive isolates, 39 (89%) were isolated from children and 5 (11%) from adults. The results show that all pneumococcal isolates were susceptible to linezolid but had varying resistance to trimethoprim-sulfamethoxazole (86%), erythromycin (73%), tetracycline (66%), clindamycin (43%), penicillin (16%), chloramphenicol (14%) and levofloxacin (2%). The range of erythromycin, tetracycline and penicillin MICs were 2 - ≥ 256 μg/mL, 4 - ≥ 48 μg/mL, and 0.047 - ≥ 256 respectively. All of the penicillin resistant isolates were multidrug resistant (MDR) and in addition to penicillin were resistant to tetracycline, erythromycin and trimethoprim-sulfamethoxazole. The most common capsular types detected in 64% of the pneumococcal isolates was 6A/B, 19A, 15A, 23F. The multilocus sequence typing (MLST) of 10 pneumococcal isolates revealed 9 different sequence types (STs), including ST 15139 (capsular type 19A) and ST 15140 (capsular type 23F), which have not previously been reported. The study revealed that the S. pneumoniae isolates belonged to diverse capsular types and clones with high rate of resistance to erythromycin, tetracycline, and penicillin.

中文翻译：

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从伊朗德黑兰的临床样本中分离出的侵袭性肺炎链球菌的分子特征，抗生素抗性模式和荚膜类型。

肺炎链球菌在世界范围内引起严重的感染。这项研究的目的是确定伊朗德黑兰的侵袭性肺炎链球菌的分子特征，抗生素抗性模式和荚膜类型。在44例肺炎球菌侵袭性分离株中，有39例（89％）分离自儿童，有5例（11％）分离自成人。结果显示，所有肺炎球菌分离株均对利奈唑胺敏感，但对甲氧苄啶-磺胺甲基异恶唑（86％），红霉素（73％），四环素（66％），克林霉素（43％），青霉素（16％），氯霉素（ 14％）和左氧氟沙星（2％）。红霉素，四环素和青霉素的MIC范围分别为2-≥256μg/ mL，4-≥48μg/ mL和0.047-≥256。所有耐青霉素的菌株均耐多药（MDR），除了青霉素还耐四环素，红霉素和甲氧苄氨嘧啶磺胺甲基恶唑。在64％的肺炎球菌分离物中检测到的最常见荚膜类型为6A / B，19A，15A，23F。10个肺炎球菌分离株的多基因座序列分型（MLST）显示了9种不同的序列类型（ST），包括ST 15139（19A型荚膜）和ST 15140（23F型荚膜），以前没有报道。研究表明，肺炎链球菌的分离物属于多种荚膜类型，且对红霉素，四环素和青霉素的耐药率较高。包括以前未曾报道过的ST 15139（19A型封装）和ST 15140（23F型封装）。研究表明，肺炎链球菌的分离物属于多种荚膜类型，且对红霉素，四环素和青霉素的耐药率较高。包括以前未曾报道过的ST 15139（19A型封装）和ST 15140（23F型封装）。研究表明，肺炎链球菌的分离物属于多种荚膜类型，且对红霉素，四环素和青霉素的耐药率较高。