Background: Clinically available cartilage, such as large-volume tissue-engineered cartilage, is urgently required for various clinical applications. Tissue engineering chamber (TEC) models are a promising organ-level strategy for efficient enlargement of cells or tissues within the chamber. The conventional TEC technology is not suitable for cartilage culture, because it lacks the necessary chondrogenic growth factor, which is present in platelet-rich plasma (PRP). In this study, we added autogenous auricular cartilage fragments mixed with PRP in a TEC to obtain a large amount of engineered cartilage.

中文翻译：

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使用无细胞培养的富含血小板的血浆在组织工程腔室中创建软骨。

背景：各种临床应用迫切需要临床可用的软骨，例如大容量组织工程软骨。组织工程腔室（TEC）模型是有效扩大腔室内细胞或组织的有希望的器官级策略。传统的TEC技术不适合软骨培养，因为它缺少富血小板血浆（PRP）中必需的软骨生长因子。在这项研究中，我们在TEC中添加了自体耳廓软骨碎片与PRP混合以获得大量工程软骨。