The emergence of multidrug-resistant (MDR) bacterial infections poses a catastrophic threat to medicine. The development of phage-based therapy combined with antibiotics might be an advantageous weapon in the arms race between human and MDR bacteria. A cocktail composed of the MDR Acinetobacter baumannii infecting bacteriophages with high lytic activity was used in combination with antibiotics to destroy a bacterial biofilm in human urine. A. baumannii exhibited varying susceptibility to the host range of bacteriophages used in this study, ranging from 56% to 84%. This study demonstrated that bacteriophages could reduce biofilm biomass in a human urine model, and some of the antibiotics commonly used in the treatment of urinary tract infection (UTI) act synergistically with phage cocktails. Additionally, the combined treatment showed a significantly greater reduction of biofilm biomass and clearance of persister cells.

中文翻译：

---

基于环境噬菌体的鸡尾酒和抗生素组合对人类尿液模型中鲍曼不动杆菌生物膜的影响。

耐多药 (MDR) 细菌感染的出现对医学构成了灾难性的威胁。基于噬菌体的疗法与抗生素相结合的发展可能是人类与耐多药细菌之间军备竞赛的有利武器。一种由 MDR鲍曼不动杆菌感染的具有高裂解活性的噬菌体组成的混合物与抗生素结合使用，以破坏人类尿液中的细菌生物膜。鲍曼不动杆菌对本研究中使用的噬菌体宿主范围表现出不同的敏感性，范围从 56% 到 84%。这项研究表明，噬菌体可以减少人类尿液模型中的生物膜生物量，并且一些常用于治疗尿路感染 (UTI) 的抗生素与噬菌体鸡尾酒协同作用。此外，联合治疗显示出生物膜生物量的显着减少和持久细胞的清除。