Launaea taraxacifolia (Asteraceae) is a widely used vegetable in West Africa. It is used in traditional healing of many diseases such as hypertension, anemia, diabetes, and bleeding. The aim of this study is to investigate the cytotoxicity and the acute and subacute (28 days) oral toxicity of L. taraxacifolia hydroethanolic leaves extract on male Wistar rats. The LC₅₀ values of L. taraxacifolia on brine shrimp were 0.142 ± 0.11 mg/mL. The limit test dose of 5000 mg/kg did not provoke death or toxicity signs in the rats tested during the observation period. For 28 days subacute toxicity at 500 and 1000 mg/kg body weight, no signs of toxicity or mortality were observed during the experiment. There was no significant difference between the treated groups and the control group concerning the body and the relative organs weight (P > .05). Results of biochemical and hematological parameters did not show any treatment-related abnormalities. According to our results, the hydroethanolic extract of L. taraxacifolia leaves, at 500 and 1000 mg/kg body weight, is safe when administrated to male Wistar rats for 28 days.

中文翻译：

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star豆（Launaea taraxacifolia（Willd）Amin Ex C. Jeffrey）的乙醇叶片提取物对Wistar大鼠的毒理学研究。

太子参（菊科）是西非广泛使用的蔬菜。它可用于许多疾病的传统治愈，例如高血压，贫血，糖尿病和出血。这项研究的目的是调查胡芦巴水合乙醇提取物对雄性Wistar大鼠的细胞毒性以及急性和亚急性（28天）口服毒性。蒲公英乳杆菌的LC ₅₀值在盐水虾上的含量为0.142±0.11 mg / mL。在观察期内，极限试验剂量5000 mg / kg不会引起死亡或毒性迹象。对于500和1000 mg / kg体重的28天亚急性毒性，在实验过程中未观察到毒性或死亡率的迹象。治疗组和对照组在身体和相对器官重量方面无显着差异（P  > .05）。生化和血液学参数的结果未显示任何与治疗相关的异常。根据我们的研究结果，当雄性Wistar大鼠使用28天时，蒲公英乳杆菌的氢乙醇提取物的重量为500和1000 mg / kg，是安全的。