Hypersonins A-D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii.,Journal of Natural Products

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Hypersonins A-D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-06-16 , DOI: 10.1021/acs.jnatprod.9b01187
Shuangshuang Xie ₁ , Xiaosheng Tan _{2,

3,

4,

5} , Yaping Liu ₁ , Yulin Duan ₁ , Gang Chen _{2,

3,

4,

5} , Hao Feng _{2,

3,

4,

5} , Lingjuan Sun _{2,

3,

4,

5} , Yingying Huang ₁ , Yi Guo ₁ , Zhengyi Shi ₁ , Yuan Zhou ₁ , Changxing Qi ₁ , Yonghui Zhang ₁

Affiliation

Hypersonins A–D (1–4), four 1,2-seco-homoadamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs) possessing a new bicyclo[4.3.1]decane-3-methoxycarbonyl architecture, were obtained from Hypericum wilsonii. The structures of hypersonins A–D were identified by spectroscopic data, electronic circular dichroism comparison, and X-ray crystallographic data. Hypersonins A–D are the first seco-homoadamantane-type PPAPs with cleavage at the C-1–C-2 bond. Hypersonin A (1) showed moderate inhibitory activity to anti-CD3/anti-CD28 monoclonal antibody-induced proliferation of murine splenocytes, with an IC₅₀ value of 8.3 ± 0.2 μM.

中文翻译：

Hypersonins AD，来自金丝桃属植物的具有 1,2-seco-高金刚烷结构的多环聚异戊二烯化酰基间苯三酚。

Hypersonins A–D ( 1 – 4 )，四个 1,2- seco - 高金刚烷型多环聚异戊二烯化酰基间苯三酚 (PPAP) 具有新的双环 [4.3.1] 癸烷-3-甲氧基羰基结构，从金丝桃中获得。通过光谱数据、电子圆二色性比较和 X 射线晶体学数据确定了超音素 A-D 的结构。Hypersonins A-d是所述第一开环-homoadamantane型PPAPs具有在C-1-C-2键裂解。Hypersonin A ( 1 ) 对抗 CD3/抗 CD28 单克隆抗体诱导的鼠脾细胞增殖显示出中等抑制活性，IC ₅₀值为 8.3 ± 0.2 μM。

更新日期：2020-06-26

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