Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities.,Journal of Natural Products

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Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-06-16 , DOI: 10.1021/acs.jnatprod.9b01283
Meilin Zhu ₁ , Xuewen Zhang ₁ , Xuenan Huang ₁ , Haotian Wang ₁ , Komal Anjum ₂ , Qianqun Gu ₂ , Tianjiao Zhu ₂ , Guojian Zhang ₃ , Dehai Li _{2,

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Affiliation

Epipolythiodioxopiperazines (ETPs) are a class of biologically active fungal secondary metabolites characterized by a bridged polysulfide piperazine ring. Regularly, the sulfide functionality is attached in the α-positions of the dioxopiperazine scaffold. However, ETPs possessing irregular sulfur bridges have rarely been explored. This review summarizes that 83 compounds of this subtype have been isolated and characterized since the discovery of gliovirin in 1982. Herein, particular emphasis is given to the isolation, chemistry, and biological activity of this subtype. For a better understanding, a relevant summary focusing on the source microorganisms and their taxonomy is provided and will help elucidate the fascinating chemistry and biology of these unusual ETPs.

中文翻译：

不规则桥接的环氧多硫二氧代哌嗪和相关类似物：来源、结构和生物活性。

Epipolythiodioxopiperazines (ETPs) 是一类具有生物活性的真菌次级代谢产物，其特征是桥接多硫哌嗪环。通常，硫化物官能团连接在二氧哌嗪支架的 α 位。然而，很少探索具有不规则硫桥的 ETP。本综述总结了自 1982 年发现 gliovirin 以来已分离和表征了该亚型的 83 种化合物。在此，特别强调该亚型的分离、化学和生物活性。为了更好地理解，提供了一个重点关注源微生物及其分类学的相关摘要，这将有助于阐明这些不寻常 ETP 的迷人化学和生物学。

更新日期：2020-06-26

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