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Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands
Journal of Chemistry ( IF 2.8 ) Pub Date : 2020-06-16 , DOI: 10.1155/2020/5414959
Quang Trung Nguyen 1, 2 , Phuong Nam Pham Thi 1 , Van Tuyen Nguyen 1, 2
Affiliation  

A series of platinum(II) complexes with chiral Schiff base ligands derived from various salicylaldehydes with (R,R′)- and (S,S′)-cyclohexanediamine were synthesized and characterized by ESI-MS, IR, and NMR. Obtained spectra with typical signals were in agreement with suggested molecular formulae of the complexes. Their photophysical properties were studied by UV-visible and emission spectroscopies. The UV-Vis showed the typical band with low energy at visible range 400–500 nm for MLCT, and this band can emit the luminescent band with emission maximum wavelengths at 529–595 nm. The in vitro cytotoxicity of obtained platinum(II) complexes was screened for KB and MCF-7 human cancer cell lines. The results showed that (S)-enantiomers were more active than (R)-enantiomers and the different positions of methoxy group in salicyl ring gave different cytotoxicities.

中文翻译:

带有手性四齿水杨醛亚胺配体的铂 (II) 配合物的合成、表征和体外细胞毒性

合成了一系列具有手性席夫碱配体的铂 (II) 配合物,这些配体来源于各种水杨醛与 (R,R')- 和 (S,S')-环己二胺,并通过 ESI-MS、IR 和 NMR 进行表征。获得的具有典型信号的光谱与建议的复合物分子式一致。通过紫外-可见光和发射光谱研究了它们的光物理特性。UV-Vis 显示 MLCT 在可见光范围 400-500 nm 处的典型低能量波段,该波段可以发射最大发射波长为 529-595 nm 的发光波段。针对 KB 和 MCF-7 人类癌细胞系筛选了获得的铂 (II) 复合物的体外细胞毒性。
更新日期:2020-06-16
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