Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications.

中文翻译：

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共轭亚油酸接枝提高了聚己内酯电纺膜的血液相容性

聚己内酯（PCL）是一种用途广泛的生物材料，具有广泛的医学应用，但由于其血液相容性不足，其在血液接触设备中的使用受到阻碍。在这项工作中，将静电纺丝的聚己内酯（PCL）膜与共轭亚油酸（CLA）化学接枝，以防止血液凝固。研究了接枝CLA的密度及其对膜的形态和润湿性的影响。该研究还调查了膜如何与人类全血和血小板相互作用，以确定其抗血栓形成特性。结果表明，接枝对膜的物理性能影响可忽略不计，但大大提高了其与血液的相容性，表明该方法可进一步用于接触血液的应用。