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The Potential of Antimicrobial Peptides as an Antiviral Therapy against COVID-19.
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-06-16 , DOI: 10.1021/acsptsci.0c00059 Sherif Elnagdy 1 , Maha AlKhazindar 1
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-06-16 , DOI: 10.1021/acsptsci.0c00059 Sherif Elnagdy 1 , Maha AlKhazindar 1
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COVID-19 is currently considered as a life-threatening pandemic viral infection. Finding an antiviral drug or a vaccine is the only route for humans’ survival against it. To date, no specific antiviral treatment has been confirmed. Antimicrobial peptides (AMPs) have been widely regarded as a promising solution to combat harmful microorganisms. They are biologically active molecules produced by different organisms as an essential component of their innate immune response against invading pathogens. Lactoferrin (LF), one of the AMPs, is an iron-binding glycoprotein that is present in several mucosal secretions. The antiviral activity of LF exists against a wide range of human and animal viruses (DNA and RNA). LF was proven to increase the host immunity against viral infection. Since LF is one of the constituents of breast milk and significantly located at the mucosal layers of the human body, it is considered the first line of defense against microbial infection. LF was reported to have antiviral activity against SARS-CoV infection. The significant antiviral activity of LF makes it a potential option as an immunity enhancer, a drug or a drug conjugate with conventional antivirals. The affordability, environmental safety, and efficiency of LFs will make them superior to all other control strategies.
中文翻译：
抗菌肽作为 COVID-19 抗病毒疗法的潜力。
COVID-19 目前被认为是一种危及生命的大流行病毒感染。寻找抗病毒药物或疫苗是人类生存的唯一途径。迄今为止，尚未证实具体的抗病毒治疗。抗菌肽（AMP）被广泛认为是对抗有害微生物的有前途的解决方案。它们是由不同生物体产生的生物活性分子，是针对入侵病原体的先天免疫反应的重要组成部分。乳铁蛋白 (LF) 是 AMP 之一，是一种铁结合糖蛋白，存在于多种粘膜分泌物中。LF 具有针对多种人类和动物病毒（DNA 和 RNA）的抗病毒活性。LF被证明可以提高宿主对病毒感染的免疫力。由于LF是母乳的成分之一，并且主要位于人体的粘膜层，因此被认为是抵抗微生物感染的第一道防线。据报道，LF 对 SARS-CoV 感染具有抗病毒活性。LF 显着的抗病毒活性使其成为免疫增强剂、药物或与传统抗病毒药物的药物缀合物的潜在选择。LF 的经济性、环境安全性和效率将使它们优于所有其他控制策略。
更新日期：2020-08-14
中文翻译：
抗菌肽作为 COVID-19 抗病毒疗法的潜力。
COVID-19 目前被认为是一种危及生命的大流行病毒感染。寻找抗病毒药物或疫苗是人类生存的唯一途径。迄今为止，尚未证实具体的抗病毒治疗。抗菌肽（AMP）被广泛认为是对抗有害微生物的有前途的解决方案。它们是由不同生物体产生的生物活性分子，是针对入侵病原体的先天免疫反应的重要组成部分。乳铁蛋白 (LF) 是 AMP 之一，是一种铁结合糖蛋白，存在于多种粘膜分泌物中。LF 具有针对多种人类和动物病毒（DNA 和 RNA）的抗病毒活性。LF被证明可以提高宿主对病毒感染的免疫力。由于LF是母乳的成分之一，并且主要位于人体的粘膜层，因此被认为是抵抗微生物感染的第一道防线。据报道，LF 对 SARS-CoV 感染具有抗病毒活性。LF 显着的抗病毒活性使其成为免疫增强剂、药物或与传统抗病毒药物的药物缀合物的潜在选择。LF 的经济性、环境安全性和效率将使它们优于所有其他控制策略。
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