ABSTRACT

Recent studies have identified host long noncoding RNAs (lncRNAs) as key regulators of host-virus interactions during viral infection. The influenza A virus (IAV) remains a serious threat to public health and economic stability. It is well known that thousands of lncRNAs are differentially expressed upon IAV infection, some of which regulate IAV infection by modulating the host innate immune response, affecting cellular metabolism, or directly interacting with viral proteins. Some of these lncRNAs appear to be required for IAV infection, but the molecular mechanisms are not completely elucidated. In this review, we summarize the roles of host lncRNAs in regulating IAV infection and provide an overview of the lncRNA-mediated regulatory network. The goal of this review is to stimulate further research on the function of both well-established and newly discovered lncRNAs in IAV infection.

摘要

最近的研究已将宿主长的非编码RNA（lncRNA）确定为病毒感染期间宿主与病毒相互作用的关键调节因子。甲型流感病毒（IAV）仍然严重威胁公众健康和经济稳定。众所周知，在IAV感染后数千个lncRNA会差异表达，其中一些可通过调节宿主固有免疫反应，影响细胞代谢或直接与病毒蛋白相互作用来调节IAV感染。这些lncRNA中的某些似乎是IAV感染所必需的，但分子机制尚未完全阐明。在这篇综述中，我们总结了宿主lncRNA在调节IAV感染中的作用，并概述了lncRNA介导的调节网络。