Objective

To review the historical, clinical, radiographic, and outcome characteristics of individuals diagnosed with an acquired brain injury (ABI) due to cerebral fat embolism syndrome (CFES) with and without features of traumatic brain injury (TBI)

Methods

A retrospective chart review of individuals with the diagnosis of CFES admitted to an ABI rehabilitation program. Cases were divided into two cohorts 1) individuals with evidence of classic features of CFES alone, and 2) individuals with evidence of CFES in conjunction with features of TBI.

Results

14 individuals were identified, seven individuals with diagnosis of CFES alone, and seven with CFES and TBI. Median initial GCS was 15 for the isolated CFES cohort and 8 for the dual diagnosis cohort (p =.006). There were clear qualitative differences in MRI findings with characteristic patterns between the two groups.

Conclusion

The diagnosis of CFES is an important consideration for individuals who have new neurologic impairment following a trauma, especially in cases where initial GCS was high. MRI has an important role in differentiating lesions of CFES from TBI and should be utilized for prognostication and management decisions. Individuals with neurologic injury secondary to CFES had good functional recovery outcomes as measured by Glasgow Outcome Scale.

中文翻译：

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脑脂肪栓塞综合征与颅脑外伤的交集：文献复习和病例系列。

目的

审查个人的历史，临床，影像学和结果特征，诊断为患有脂肪性肝栓塞综合症（CFES）且具有和不具有创伤性脑损伤（TBI）特征的获得性脑损伤（ABI）

方法

回顾性图表回顾了被确诊为CFES的ABI康复计划患者。将病例分为两个队列：1）仅具有CFES经典特征的个体，以及2）具有CFES和TBI特征的个体。

结果

确定了14个人，其中7个人诊断为CFES，另外7个人诊断为CFES和TBI。单独的CFES队列的初始GCS中位数为15，双重诊断队列的初始GCS中位数为8（p = .006）。两组之间的MRI特征特征模式存在明显的质量差异。

结论

对于创伤后有新的神经系统损害的患者，尤其是初始GCS较高的患者，CFES的诊断是重要的考虑因素。MRI在区分CFES和TBI病变方面起着重要作用，应用于预后和治疗决策。格拉斯哥成果量表显示，继发于CFES的神经系统损伤患者的功能恢复良好。