ABSTRACT

Fracture in the hip joint is a major and quite common health issue, particularly for the elderly. The loads exploited by the lower limbs are very acute and severe; in the femur, they can be several folds higher than the whole weight of the body. Nanotechnology and nanocomposites offer great potential in biomedical applications. The organic materials are more biocompatible. Mechanical properties like strength and hardness are challenging parameters which control the selection of a joint. HDPE in its pure form has been successfully used as a prosthetic foot (external) but failed as an implant material due to limited mechanical properties. High-density polyethylene thermoplastic polymer (HDPE) and multi-walled carbon nanotubes (MWCNT)/Nano-Alumina is selected as a potential material for a biomedical implant and its mechanical properties and biocompatibility have been discussed. HDPE/MWCNT/Alumina (Al₂O₃) nanocomposites have not been explored yet for prosthetic implants. These nanocomposites were prepared in this investigation in different compositions. Prepared material has been physiochemically characterized to check the morphology and the structure. MWCNTs enhanced hardness and elastic modulus of the HDPE. Optimization of the material composition revealed that hybrid composite with structure (2.4% Al₂O₃ and 0.6% MWCNT) exhibits better mechanical properties compared to other ratios with 3% MWCNTs and 5% MWCNTs. Thermal gravimetric analysis (TGA) dedicates that the percentage of crystallization has been increased to 6% after adding MWCNT to HDPE. The moisture absorption decreased to 90% with 5% MWCNT. Experimental results of Colorimetric assay (MTT) of a normal human epithelial cell line (1- BJ1) over Al₂O₃/MWCNT@HDPE showed <20% cytotoxic activity, proving its acceptance for medical use. HDPE/MWCNT/Al₂O₃ nanocomposites emerged as a candidate material for artificial joints.

摘要

髋关节骨折是一个主要且非常普遍的健康问题，尤其是对于老年人而言。下肢承受的负荷非常严重。在股骨中，它们可能比身体的整体重量高出几倍。纳米技术和纳米复合材料在生物医学应用中具有巨大的潜力。有机材料具有更高的生物相容性。诸如强度和硬度之类的机械性能是具有挑战性的参数，这些参数控制着接头的选择。纯粹形式的HDPE已成功用作假足（外部），但由于有限的机械性能而未能用作植入材料。选择高密度聚乙烯热塑性聚合物（HDPE）和多壁碳纳米管（MWCNT）/纳米氧化铝作为生物医学植入物的潜在材料，并对其机械性能和生物相容性进行了讨论。HDPE / MWCNT /氧化铝（铝₂ O ₃）纳米复合材料尚未用于假体植入。这些纳米复合材料在本研究中以不同的组成制备。已对制备的材料进行了物理化学表征，以检查其形态和结构。MWCNT提高了HDPE的硬度和弹性模量。材料成分的优化表明，杂化复合材料的结构（2.4％Al ₂ O ₃与含3％MWCNT和5％MWCNT的其他比例相比，它们的机械性能更好。热重分析（TGA）表明，向HDPE中添加MWCNT后，结晶百分比已增加至6％。用5％的MWCNT将水分吸收降低至90％。在Al ₂ O ₃ / MWCNT @ HDPE上对正常人上皮细胞系（1- BJ1）进行比色测定（MTT）的实验结果显示，其细胞毒性活性小于20％，证明了其在医学上的可接受性。HDPE / MWCNT / Al ₂ O ₃纳米复合材料作为人工关节的候选材料出现。