Abstract

Exosomes are small membrane vesicles released by most eukaryotic cells. They are considered to play an essential role in cell-to-cell communication, and It is also found that they serve as functional mediators in many severe diseases, including progression of various types of cancers. Inhibition of exosome release may slow the progression of some cancers; thus, exosome has been an attractive target for cancer treatment. Over the years, considerable efforts have been made to discover novel, highly potent and excellently selective exosome inhibitors. Most of these inhibitors are derived from synthetic compounds, some of which are currently existed drugs and found to have the potential to inhibit exosome release. In this review, we briefly discussed the development of exosome inhibitors that are currently discovered and provided guidance for the future development of inhibitors.

摘要

外泌体是大多数真核细胞释放的小膜囊泡。它们被认为在细胞间通讯中发挥重要作用，并且还发现它们在许多严重疾病（包括各种类型癌症的进展）中充当功能介质。抑制外泌体释放可能会减缓某些癌症的进展；因此，外泌体一直是癌症治疗的一个有吸引力的靶点。多年来，人们为发现新型、高效且选择性极佳的外泌体抑制剂付出了巨大的努力。这些抑制剂大多数源自合成化合物，其中一些是目前存在的药物，并被发现具有抑制外泌体释放的潜力。在这篇综述中，我们简要讨论了目前发现的外泌体抑制剂的发展，并为抑制剂的未来发展提供指导。