Abstract

The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for health-care systems worldwide. Many different risk factors are associated with disease severity, such as older age, diabetes, hypertension, and most recently obesity. The incidence of obesity has been on the rise for the past 25 years, reaching over 2 billion people throughout the world, and obesity itself could be considered a pandemic. In this review, we summarize aspects involved with obesity, such as changes in the immune response, nutritional factors, physiological factors, and the gut-lung axis, that impact the viral response and the COVID-19 prognosis.

摘要

当前的 2019 年冠状病毒病 (COVID-19) 大流行对全球卫生保健系统提出了巨大挑战。许多不同的风险因素与疾病的严重程度有关，例如年龄较大、糖尿病、高血压和最近的肥胖症。在过去的 25 年里，肥胖的发病率一直在上升，全球超过 20 亿人，肥胖本身可以被视为一种流行病。在这篇综述中，我们总结了与肥胖相关的方面，例如影响病毒反应和 COVID-19 预后的免疫反应、营养因素、生理因素和肠-肺轴的变化。