A vaccine to protect against COVID-19 is urgently needed. Such a vaccine should efficiently induce high-affinity neutralizing antibodies which neutralize SARS-CoV-2, the cause of COVID-19. However, there is a concern regarding both vaccine-induced eosinophilic lung disease and eosinophil-associated Th2 immunopotentiation following infection after vaccination. Here, we review the anticipated characteristics of a COVID-19 vaccine to avoid vaccine-associated eosinophil immunopathology.
Int Arch Allergy Immunol

中文翻译：

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与COVID-19疫苗接种和感染相关的SARS-CoV-2-介导的嗜酸性粒细胞疾病的预防策略。

迫切需要一种预防COVID-19的疫苗。这种疫苗应有效诱导高亲和力的中和抗体，该抗体可中和SARS-CoV-2（COVID-19的病因）。然而，在疫苗接种后感染后，疫苗引起的嗜酸性粒细胞性肺疾病和嗜酸性粒细胞相关的Th2免疫增强都令人担忧。在这里，我们审查了COVID-19疫苗的预期特性，以避免与疫苗相关的嗜酸性粒细胞免疫病理学。
Int Arch过敏免疫