Abstract The synthesis of collagen–hydroxyapatite composites has been carried out, and the biocompatibility and osteoconductivity properties have been tested. This research was conducted to determine the ability of hydroxyapatite–collagen composites to support the bone growth through the graft surface. Hydroxyapatite used in this study was synthesized from coral with a purity of 96.6%, while collagen was extracted from the chicken claw. The process of forming a scaffold of collagen–hydroxyapatite composites was carried out using the freeze-drying method at −80°C for 4 h. The biocompatibility characteristics of the sample through the cytotoxicity tests showed that the percentage of viable cells in collagen–hydroxyapatite biocomposite was 108.2%, which is higher than the percentage of viable cells of hydroxyapatite or collagen material. When the viable cell is above 100%, collagen–hydroxyapatite composites have excellent osteoconductivity as a material for bone regeneration.

中文翻译：

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骨再生支架多孔复合胶原-羟基磷灰石珊瑚的生物相容性和骨传导性

摘要 开展了胶原-羟基磷灰石复合材料的合成，并对其生物相容性和骨传导性进行了测试。进行这项研究是为了确定羟基磷灰石 - 胶原复合材料通过移植物表面支持骨骼生长的能力。本研究中使用的羟基磷灰石是由珊瑚合成的，纯度为 96.6%，而胶原蛋白是从鸡爪中提取的。使用冷冻干燥法在-80°C 下进行 4 小时的胶原-羟基磷灰石复合材料支架的形成过程。样品的生物相容性特征通过细胞毒性试验表明，胶原-羟基磷灰石生物复合材料的活细胞百分比为108.2%，高于羟基磷灰石或胶原材料的活细胞百分比。