Abstract Introduction Sheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the Jaagsiekte sheep retrovirus. Since effective treatment and a vaccination procedure are not currently possible, control and eradication of the disease is difficult. It leads to serious economic losses around the world, therefore studies are currently underway in order to design control and eradication programmes. In this study, levels and changes in selected tumour markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA 19-9, CA 15-3, and alphafetoprotein (AFP)-3) and their diagnostic significance were investigated. Material and Methods A total of 30 sheep were used. Clinical examinations were performed and blood samples were obtained before slaughter from all animals with presumed OPA. Blood samples with positive OPA results by macroscopic and histopathological examination were included in the study as the experimental group and numbered 20. Sheep totalling 10 had negative OPA results and provided control samples. Results CEA levels were similar in both groups, and the differences were statistically insignificant (P > 0.05). CA 125, CA 19-9, CA 15-3, and AFP-3 levels were higher in the OPA group than the control group and with statistical significance (P < 0.05). In all OPA animals, CA 125 levels were higher than 1 U/mL. Conclusion serum CAs and AFP levels increase significantly in adenomatous sheep. These tumour markers are thought to facilitate the diagnosis of OPA.

中文翻译：

---

患有肺腺瘤病的绵羊的选定肿瘤生物标志物水平

摘要 介绍羊肺腺瘤病（ovineplungaryadenomasis，OPA，Jaagsiekte）是由Jaagsiekte羊逆转录病毒引起的一种慢性传染性支气管肺泡癌。由于目前无法进行有效的治疗和疫苗接种程序，因此控制和根除该疾病很困难。它在世界各地造成严重的经济损失，因此目前正在进行研究，以设计控制和根除计划。在本研究中，研究了选定肿瘤标志物（癌胚抗原 (CEA)、碳水化合物抗原 (CA) 125、CA 19-9、CA 15-3 和甲胎蛋白 (AFP)-3）的水平和变化及其诊断意义。材料和方法总共使用30只羊。在屠宰前对所有疑似患有 OPA 的动物进行了临床检查并采集了血样。肉眼和组织病理学检查结果呈阳性的血样纳入本研究作为实验组，编号为20只。绵羊共10只，OPA结果呈阴性，并提供对照样本。结果 两组CEA水平相似，差异无统计学意义（P>0.05）。OPA组CA 125、CA 19-9、CA 15-3、AFP-3水平高于对照组，差异有统计学意义（P < 0.05）。在所有 OPA 动物中，CA 125 水平均高于 1 U/mL。结论 腺瘤羊血清CAs、AFP水平显着升高。这些肿瘤标志物被认为有助于 OPA 的诊断。