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Iron‐Promoted Domino Dehydrogenative Annulation of Deoxybenzoins and Alkynes Leading to β‐Aryl‐α‐Naphthols
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2020-06-15 , DOI: 10.1002/adsc.202000625
Xue‐Qing Zhu 1 , Rui‐Li Guo 1 , Xing‐Long Zhang 1 , Ya‐Ru Gao 1 , Qiong Jia 1 , Yong‐Qiang Wang 1
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A strategy for synthesis of β‐aryl‐α‐naphthols has been established through an iron‐promoted domino C(sp 3)−H/C(sp )−H and C(sp 2)−H/C(sp )−H dehydrogenative coupling of deoxybenzoins and alkynes. The synthesis uses inexpensive materials with a broad substrate scope and features simple operations with excellent regioselectivity. This study provides an alternative access to various β‐aryl‐α‐naphthols and the synthetic protocol should have potential applications in medicinal, materials science, and related areas.

中文翻译:

铁促进的脱氧安息香素和炔烃的多米诺脱氢环化反应导致β-芳基-α-萘酚

通过铁促进的多米诺骨牌C(sp 3)-H / C(sp)-H和C(sp 2)-H / C(sp)-H建立了合成β-芳基-α-萘酚的策略。脱氧苯偶姻和炔烃的脱氢偶联。该合成使用廉价的材料,具有广泛的底物范围,并且具有操作简便,区域选择性高的特点。这项研究为各种β-芳基-α-萘酚提供了替代途径,合成方案应在医学,材料科学和相关领域具有潜在的应用。
更新日期:2020-08-04
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