The strategic importance for cellular organelles of being in contact with each other, exchanging messenger molecules, is nowadays well established. Different inter‐organelle cross‐talk pathways finely regulate multiple physiological cellular mechanisms, and their dysregulation has been found to underlie different pathological conditions. In the last years, a great effort has been made to study such organelle interactions, to understand their functional roles within the cell and the molecules involved in their formation and/or modulation. In this contribution, some examples of organelle cross‐talk and their contributions in regulating physiological processes are presented. Moreover, the pro and cons of the available methods for a proper, reliable investigation of membrane contact sites are described.

中文翻译：

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更好地保持联系：调查组织间的串扰

如今，对于彼此接触，交换信使分子的细胞器而言，其战略重要性已得到公认。不同的细胞间串扰通路可以很好地调节多种生理细胞机制，并且发现它们的失调是不同病理条件的基础。在过去的几年中，已经作出巨大的努力来研究这种细胞器的相互作用，以了解它们在细胞内的功能作用以及参与其形成和/或调节的分子。在此贡献中，提供了一些细胞器串扰的示例及其在调节生理过程中的贡献。此外，描述了正确，可靠地研究膜接触部位的可用方法的优缺点。