In intensity‐modulated proton therapy (IMPT), unaccounted‐for variation in biological effectiveness contributes to the discrepancy between the constant relative biological effectiveness (RBE) model prediction and experimental observation. It is desirable to incorporate biological doses in treatment planning to improve modeling accuracy and consequently achieve a higher therapeutic ratio. This study addresses this demand by developing a method to incorporate linear energy transfer (LET) into beam orientation optimization (BOO).

中文翻译：

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用于调强质子治疗的线性能量转移加权光束方向优化

在调强质子治疗 (IMPT) 中，生物有效性中无法解释的变化导致恒定相对生物有效性 (RBE) 模型预测与实验观察之间的差异。需要在治疗计划中加入生物剂量以提高建模准确性并因此实现更高的治疗率。本研究通过开发一种将线性能量转移 (LET) 纳入光束定向优化 (BOO) 的方法来满足这一需求。