Doping Polysulfone Membrane with Alpha-Tocopherol and Alpha-Lipoic Acid for Suppressing Oxidative Stress Induced by Hemodialysis Treatment.,Macromolecular Bioscience

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Doping Polysulfone Membrane with Alpha-Tocopherol and Alpha-Lipoic Acid for Suppressing Oxidative Stress Induced by Hemodialysis Treatment.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-06-15 , DOI: 10.1002/mabi.202000046
Michaela Kohlová _{1,

2} , Susana Rocha ₁ , Célia Gomes Amorim ₁ , Alberto de Nova Araújo ₁ , Alice Santos-Silva ₃ , Petr Solich ₂ , Maria Conceição Branco da Silva Montenegro ₁

Affiliation

The reduction of free radicals by bioactive membranes used for hemodialysis treatment is an important topic due to the constant rise of oxidative stress‐associated cardiovascular mortality by hemodialysis patients. Therefore, it is urgent to find an effective solution that helps to solve this problem. Polysulfone membranes enriched with α‐lipoic acid, α‐tocopherol, and with both components are fabricated by spin coating. The antioxidant properties of these membranes are evaluated in vitro by determining the lipid‐peroxidation level and the total antioxidant status of the blood plasma. The biocompatibility is assessed by quantifying the protein adsorption, platelet adhesion, complement activation, and hemolytic effect. All types of membranes show in vitro antioxidant activity and a trend to reduce oxidative stress in vivo; the best results show membranes prepared with a combination of both compounds and prove to be nonhemolytic and hemocompatible. Moreover, the membrane specific separation ability for the main waste products is not affected by antioxidants incorporation.

中文翻译：

用α-生育酚和α-硫辛酸掺杂聚砜膜以抑制血液透析治疗引起的氧化应激。

由于血液透析患者不断增加的与氧化应激相关的心血管疾病死亡率，用于血液透析治疗的生物活性膜减少自由基是一个重要的课题。因此，迫切需要找到有助于解决该问题的有效解决方案。通过旋涂制备富含α-硫辛酸，α-生育酚以及两种成分的聚砜膜。通过确定脂质过氧化水平和血浆中的总抗氧化剂状态，可以体外评估这些膜的抗氧化剂特性。通过定量蛋白质吸附，血小板粘附，补体激活和溶血作用来评估生物相容性。所有类型的膜均显示出体外抗氧化活性，并有降低体内氧化应激的趋势。最好的结果表明，用两种化合物组合制备的膜具有非溶血性和血液相容性。而且，主要废物的膜比分离能力不受抗氧化剂掺入的影响。

更新日期：2020-06-15

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