Seizures are a well‐recognized and often prominent manifestation of autoimmune encephalitic syndromes. Progress in detection of pathogenic neural autoantibodies has led to increased awareness of autoimmune causes of seizures. Clinical studies of patients with these autoantibodies have improved our understanding of the seizure characteristics, treatments, and seizure prognosis in these disorders. The International League Against Epilepsy (ILAE) Autoimmunity and Inflammation Taskforce proposes conceptual definitions for two main diagnostic entities: (a) acute symptomatic seizures secondary to autoimmune encephalitis, and (b) autoimmune‐associated epilepsy, the latter of which suggests an enduring predisposition to seizures. Such a distinction is relevant when discussing the pathophysiology, treatment, prognosis, and social consequences of these disorders. We discuss the role of biomarkers in the application of these conceptual definitions and illustrate their use in patients cared for by members of the task force.

中文翻译：

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继发于自身免疫性脑炎和自身免疫性癫痫的急性症状性癫痫：概念定义

癫痫发作是自身免疫性脑炎综合征的公认且通常是突出的表现。致病性神经自身抗体检测的进展导致人们对癫痫发作的自身免疫原因的认识提高。对具有这些自身抗体的患者的临床研究提高了我们对这些疾病的癫痫发作特征、治疗和癫痫发作预后的理解。国际抗癫痫联盟 (ILAE) 自身免疫和炎症工作组提出了两个主要诊断实体的概念定义：(a) 继发于自身免疫性脑炎的急性症状性癫痫发作，和 (b) 自身免疫相关性癫痫，后者表明其具有持久的易感性癫痫发作。在讨论病理生理学、治疗、预后、和这些疾病的社会后果。我们讨论了生物标志物在这些概念定义的应用中的作用，并说明了它们在由工作组成员照顾的患者中的应用。