Eukaryotic membrane‐bound organelles, exhibiting distinctive morphologies, dynamics and functions, are interconnected at membrane contact sites (MCSs) through numerous tethering machineries. MCSs are required for many fundamental cellular processes, such as non‐vesicular lipid transfer, calcium transport and organelle homeostasis. Actin cytoskeleton and myosin motors are known to dynamically interact with different membrane boundaries, facilitating organelle movements and partitioning. Intriguingly, recent studies have pinpointed a special participation of actomyosin at various MCSs involving the endoplasmic reticulum (ER), the most extensive membranous organelle in the cell. Here, I summarize emerging roles of ER MCSs in modulating actomyosin structures and discuss feedback functions of such actomyosin regulation at these MCSs.

中文翻译：

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内质网膜接触与肌动球蛋白细胞骨架之间的相互作用。

表现出独特的形态，动力学和功能的真核细胞膜结合细胞器通过许多束缚装置在膜接触部位（MCS）相互连接。MCS是许多基本细胞过程所必需的，例如非囊泡脂质转移，钙转运和细胞器动态平衡。已知肌动蛋白的细胞骨架和肌球蛋白运动与不同的膜边界动态相互作用，促进细胞器的运动和分配。有趣的是，最近的研究指出了肌动球蛋白特别参与各种涉及内质网（ER）的MCS，内质网是细胞中最广泛的膜细胞器。在这里，我总结了ER MCS在调节放线菌素结构中的新兴作用，并讨论了在这些MCS上这种放线菌素调节的反馈功能。