Development of Cell Spheroids by Advanced Technologies,Advanced Materials Technologies

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Development of Cell Spheroids by Advanced Technologies
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2020-06-16 , DOI: 10.1002/admt.202000183
Changmin Shao ₁ , Junjie Chi ₂ , Hui Zhang ₃ , Qihui Fan ₄ , Yuanjin Zhao _{1,

2} , Fangfu Ye _{1,

4}

Affiliation

3D cell culture has been strongly advocated as a highly useful culture technique instead of the traditional 2D cell culture. Specially, spheroids, as the primary mode of 3D cell culture, allow cells to establish a connection between the cell and the extracellular matrix to form a specific 3D structure that better mimics the growing environment of cells in vivo. Benefiting from the emergence of various advanced micromachining platforms, spheroids have received increasing attention in diverse fields. Herein, the combination of the cell spheroid culture with microfluidic technology is reviewed. After concisely introducing the traditional methods for fabricating cell spheroids, an outline of the approaches for preparing cell spheroids using different advanced techniques is given. Then, the various applications of the generated cell spheroids in the field of biomedical engineering are presented and the current limitations, challenges, and future directions are summarized.

中文翻译：

利用先进技术开发细胞球体

强烈提倡3D细胞培养是一种非常有用的培养技术，而不是传统的2D细胞培养。特别地，球体是3D细胞培养的主要模式，它使细胞能够在细胞和细胞外基质之间建立连接，从而形成一种特定的3D结构，从而更好地模拟体内细胞的生长环境。得益于各种先进的微加工平台的出现，球体在各个领域受到越来越多的关注。在此，综述了细胞球状培养与微流技术的结合。在简要介绍了制造细胞球体的传统方法之后，概述了使用不同先进技术制备细胞球体的方法。然后，

更新日期：2020-06-16

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