Clinical descriptions about influenza-like illnesses (ILI) in COVID-19 seem non-specific. We aimed to compare the clinical features of COVID-19 and influenza. We retrospectively investigated the clinical features and outcomes of confirmed cases of COVID-19 and influenza in Nord Franche-Comté Hospital between February 26th and March 14th 2020. We used SARS-CoV-2 RT-PCR and influenza virus A/B RT-PCR in respiratory samples to confirm the diagnosis. We included 124 patients. The mean age was 59 (±19 [19–98]) years with 69% female. 70 patients with COVID-19 and 54 patients with influenza A/B. Regarding age, sex and comorbidities, no differences were found between the two groups except a lower Charlson index in COVID-19 group (2 [±2.5] vs 3 [±2.4],p = 0.003). Anosmia (53% vs 17%,p < 0.001), dysgeusia (49% vs 20%,p = 0.001), diarrhea (40% vs 20%,p = 0.021), frontal headache (26% vs 9%,p = 0.021) and bilateral cracklings sounds (24% vs 9%,p = 0.034) were statistically more frequent in COVID-19. Sputum production (52% vs 29%,p = 0.010), dyspnea (59% vs 34%,p = 0.007), sore throat (44% vs 20%,p = 0.006), conjunctival hyperhemia (30% vs 4%,p < 0.001), tearing (24% vs 6%,p = 0.004), vomiting (22% vs 3%,p = 0.001) and rhonchi sounds (17% vs 1%,p = 0.002) were more frequent with influenza infection. We described several clinical differences which can help the clinicians during the co-circulation of influenza and SARS-CoV-2.

关于 COVID-19 中流感样疾病 (ILI) 的临床描述似乎不具体。我们的目的是比较 COVID-19 和流感的临床特征。我们回顾性调查了 2020 年 2 月 26 日至 3 月 14 日期间北弗朗什孔泰医院确诊的 COVID-19 和流感病例的临床特征和结果。我们使用了 SARS-CoV-2 RT-PCR 和流感病毒 A/B RT-PCR检测呼吸道样本以确诊。我们纳入了 124 名患者。平均年龄为 59 (±19 [19–98]) 岁，其中 69% 为女性。70 名 COVID-19 患者和 54 名甲型/乙型流感患者。关于年龄、性别和合并症，除了 COVID-19 组的查尔森指数较低（2 [±2.5] vs 3 [±2.4]， p  = 0.003）外，两组之间没有发现差异。嗅觉缺失（53% vs 17%，p  < 0.001）、味觉障碍（49% vs 20%，p  = 0.001）、腹泻（40% vs 20%，p  = 0.021）、额头头痛（26% vs 9%，p  = 0.021）和双侧爆裂声（24% vs 9%，p  = 0.034）在 COVID-19 中统计上更为频繁。咳痰（52% vs 29%，p  = 0.010）、呼吸困难（59% vs 34%，p  = 0.007）、喉咙痛（44% vs 20%，p  = 0.006）、结膜充血（30% vs 4%，p  < 0.001）、流泪（24% vs 6%，p  = 0.004）、呕吐（22% vs 3%，p  = 0.001）和干啰音（17% vs 1%，p  = 0.002）在流感感染中更常见。我们描述了一些临床差异，这些差异可以在流感和 SARS-CoV-2 共同传播期间为临床医生提供帮助。