This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on language and publication period. The study was registered in the PROSPERO systematic analysis database (Protocol No. CRD42017078236) and was prepared according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The following databases were used: PubMed, BVS Regional Portal, Embase, CINAHL and Web of Science. We utilized the Newcastle-Ottawa Scale to assess the methodological quality of published studies and the Kappa coefficient to assess the agreement level between two reviewers. Of the total 1156 studies retrieved by the search strategy, 28 were considered potentially eligible (Kappa test = 0.928). Of the 28 studies, three fully met the inclusion criteria. These indicated that pulmonary lesions, such as bronchiectasis and bronchitis/bronchiolitis, were observed in patients with HTLV-1, with high-resolution computed tomography of the chest being the main method of diagnostic investigation. The analyzed cohort and case-control studies indicated an etiological relationship between HTLV-1 infection and the presence of lung lesions, with emphasis on bronchiectasis in the presence of high viral loads, as well as a higher mortality in these individuals compared with the general population.

这项研究分析了人类1型T细胞淋巴病毒（HTLV-1）感染与肺系统变化之间的关系。考虑了队列和病例对照研究模型，该模型分析了HTLV-1与肺系统变化之间的因果关系。语言和出版时间没有限制。该研究已在PROSPERO系统分析数据库（协议编号CRD42017078236）中进行了注册，并根据系统评价和荟萃分析的首选报告项目的建议进行了准备。使用了以下数据库：PubMed，BVS区域门户网站，Embase，CINAHL和Web of Science。我们使用纽卡斯尔-渥太华量表来评估已发表研究的方法学质量，并使用卡帕系数来评估两位审稿人之间的协议水平。通过搜索策略检索到的总计1156项研究中，有28项被认为具有潜在资格（Kappa检验= 0.928）。在这28项研究中，有3项完全符合纳入标准。这些表明在HTLV-1患者中观察到了肺部病变，例如支气管扩张和支气管炎/细支气管炎，胸部的高分辨率计算机断层摄影是诊断研究的主要方法。经过分析的队列研究和病例对照研究表明，HTLV-1感染与肺部病变之间存在病因学关系，尤其是在病毒载量较高的情况下，支气管扩张症的发病率与普通人群相比较高。 。三个完全符合纳入标准。这些表明在HTLV-1患者中观察到了肺部病变，例如支气管扩张和支气管炎/细支气管炎，胸部的高分辨率计算机断层摄影是诊断研究的主要方法。经过分析的队列研究和病例对照研究表明，HTLV-1感染与肺部病变之间存在病因学关系，尤其是在病毒载量较高的情况下，支气管扩张症的发病率与普通人群相比较高。 。三个完全符合纳入标准。这些表明在HTLV-1患者中观察到了肺部病变，例如支气管扩张和支气管炎/细支气管炎，胸部的高分辨率计算机断层摄影是诊断研究的主要方法。经过分析的队列研究和病例对照研究表明，HTLV-1感染与肺部病变之间存在病因学关系，尤其是在病毒载量较高的情况下，支气管扩张症的发病率与普通人群相比较高。 。