当前位置：
X-MOL 学术
›
J. Neuroimmunol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Role of gut microbiota in the GBR12909 model of mania-like behavior in mice
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jneuroim.2020.577292 Aline Silva de Miranda 1 , Érica Leandro Marciano Vieira 2 , Juliana Dos Reis Bastos 3 , Rodrigo Novaes Ferreira 4 , Jacques R Nicoli 5 , Mauro Martins Teixeira 6 , Leda Quercia Vieira 6 , Fabrício A Moreira 3 , Antônio Lúcio Teixeira 7
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jneuroim.2020.577292 Aline Silva de Miranda 1 , Érica Leandro Marciano Vieira 2 , Juliana Dos Reis Bastos 3 , Rodrigo Novaes Ferreira 4 , Jacques R Nicoli 5 , Mauro Martins Teixeira 6 , Leda Quercia Vieira 6 , Fabrício A Moreira 3 , Antônio Lúcio Teixeira 7
Affiliation
|
Growing evidence suggests a role for brain-gut-microbiota axis in affective disorders including major depression and bipolar disorder (BD). Herein, we aim to explore, by employing germ-free (GF) mice, the effect of the indigenous microbiota in the development of mania-like behavior. Conventional and GF mice were evaluated for the hyperlocomotion induced by the dopamine transporter inhibitor GBR12909 (15 mg/Kg), a validated model for mania-like behavior. Inflammatory mediators and neurotrophic factors were quantified in the prefrontal cortex, hippocampus and striatum. Mice lacking indigenous microbiota were less susceptible to the mania-like behavior induced by GBR12909. This effect was associated with decreased levels of inflammatory cytokines such as IL-6 and TNF-α, along with increased concentrations of anti- inflammatory cytokines (IL-10) and of neurotrophins (BDNF and NGF). We provided the first evidence that gut-microbiota-brain axis participates in the development of mania-like behavior in rodents, possibly through neuroimmunepathways.
中文翻译：
肠道微生物群在 GBR12909 小鼠躁狂样行为模型中的作用
越来越多的证据表明，脑-肠-微生物群轴在包括重度抑郁症和双相情感障碍 (BD) 在内的情感障碍中发挥着重要作用。在此，我们的目标是通过使用无菌（GF）小鼠来探索本土微生物群对躁狂样行为发展的影响。评估了传统小鼠和 GF 小鼠由多巴胺转运蛋白抑制剂 GBR12909（15 毫克/千克）诱导的过度运动，这是一种经过验证的躁狂样行为模型。对前额皮质、海马和纹状体中的炎症介质和神经营养因子进行了定量。缺乏本地微生物群的小鼠不太容易受到 GBR12909 诱导的躁狂样行为的影响。这种效应与炎症细胞因子（如 IL-6 和 TNF-α）水平的降低以及抗炎细胞因子（IL-10）和神经营养因子（BDNF 和 NGF）浓度的增加有关。我们提供了第一个证据，表明肠道-微生物群-大脑轴可能通过神经免疫途径参与啮齿类动物躁狂样行为的发展。
更新日期：2020-09-01
中文翻译：
肠道微生物群在 GBR12909 小鼠躁狂样行为模型中的作用
越来越多的证据表明，脑-肠-微生物群轴在包括重度抑郁症和双相情感障碍 (BD) 在内的情感障碍中发挥着重要作用。在此，我们的目标是通过使用无菌（GF）小鼠来探索本土微生物群对躁狂样行为发展的影响。评估了传统小鼠和 GF 小鼠由多巴胺转运蛋白抑制剂 GBR12909（15 毫克/千克）诱导的过度运动，这是一种经过验证的躁狂样行为模型。对前额皮质、海马和纹状体中的炎症介质和神经营养因子进行了定量。缺乏本地微生物群的小鼠不太容易受到 GBR12909 诱导的躁狂样行为的影响。这种效应与炎症细胞因子（如 IL-6 和 TNF-α）水平的降低以及抗炎细胞因子（IL-10）和神经营养因子（BDNF 和 NGF）浓度的增加有关。我们提供了第一个证据，表明肠道-微生物群-大脑轴可能通过神经免疫途径参与啮齿类动物躁狂样行为的发展。
京公网安备 11010802027423号