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Caspase-8 and FADD: Where Cell Death and Inflammation Collide.
Immunity ( IF 25.5 ) Pub Date : 2020-06-16 , DOI: 10.1016/j.immuni.2020.05.008 Marcelo Pires Amaral 1 , Karina Ramalho Bortoluci 1
中文翻译:
Caspase-8和FADD:细胞死亡和炎症相撞的地方。
更新日期:2020-06-16
Immunity ( IF 25.5 ) Pub Date : 2020-06-16 , DOI: 10.1016/j.immuni.2020.05.008 Marcelo Pires Amaral 1 , Karina Ramalho Bortoluci 1
Affiliation
Caspase-8 is a master regulator of cell death pathways, although its regulation during inflammation remains elusive. Using elegant mouse genetic approaches, Schwarzer et al. and Tummers et al. revealed the importance of FADD in regulating caspase-8-mediated inflammatory responses and gut homeostasis.
中文翻译:
Caspase-8和FADD:细胞死亡和炎症相撞的地方。
Caspase-8是细胞死亡途径的主要调节剂,尽管其在炎症过程中的调节作用仍然难以捉摸。使用优雅的小鼠遗传方法,Schwarzer等。和Tummers等。揭示了FADD在调节caspase-8介导的炎症反应和肠道稳态中的重要性。