Most autoimmunity-associated SNPs in the genome map to noncoding regulatory regions in T cells, but the nature of underlying epigenetic mechanisms and any normal purpose in T cell differentiation remain unclear. In this issue of Immunity, Ohkura et al. establish that crucial SNPs linked to autoimmune disease are enriched in DNA regions of CpG demethylation that govern Treg cell development and function.

中文翻译：

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遗传学在Treg细胞和自身免疫中遇到表观遗传学。

基因组中大多数与自身免疫相关的SNP定位于T细胞中的非编码调控区，但是尚不清楚潜在表观遗传机制的性质以及T细胞分化的任何正常目的。在本期《免疫》中，大仓等人 证实与自身免疫性疾病相关的关键SNP在控制Treg细胞发育和功能的CpG脱甲基DNA区域富集。