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Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents.
Drug Discovery Today ( IF 6.5 ) Pub Date : 2020-06-16 , DOI: 10.1016/j.drudis.2020.06.006
Yasmine Alyassin 1 , Elshaimaa G Sayed 2 , Prina Mehta 1 , Ketan Ruparelia 1 , Muhammad S Arshad 1 , Manoochehr Rasekh 3 , Jennifer Shepherd 4 , Israfil Kucuk 5 , Philippe B Wilson 6 , Neenu Singh 1 , Ming-Wei Chang 7 , Dimitrios G Fatouros 8 , Zeeshan Ahmad 1
Affiliation  

Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.



中文翻译:

介孔二氧化硅纳米粒子作为化疗药物药物递送载体的应用。

最近,显着的努力集中在研究增强和提供有效和先进的治疗剂。尽管这涉及重大挑战,但已经探索了创新技术和材料来克服这些挑战。介孔二氧化硅纳米粒子 (MSN) 的优势特性,例如独特的形态和几何形状,有利于用于各种药物递送靶向目的,特别是在癌症治疗中。正如我们在此讨论的,在过去的几十年中,MSN 已被用于提高抗癌药物的效率,方法是提高它们的溶解度,使其适用于应用,减少副作用,并提高它们的抗癌细胞毒性效率。

更新日期:2020-08-19
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