Abstract Introduction Adipose tissue secretes various bioactive peptides/proteins, immune molecules and inflammatory mediators which are known as adipokines or adipocytokines. Adipokines play important roles in the maintenance of energy homeostasis, appetite, glucose and lipid metabolism, insulin sensitivity, angiogenesis, immunity and inflammation. Enormous number of studies from all over the world proved that adipocytokines are involved in the pathogenesis of diseases affecting nearly all body systems, which raises the question whether we can always blame adipocytokines as the triggering factor of every disease that may hit the body. Objective Our review targeted the role played by adipocytokines in the pathogenesis of different diseases affecting different body systems including diabetes mellitus, kidney diseases, gynecological diseases, rheumatologic disorders, cancers, Alzheimer’s, depression, muscle disorders, liver diseases, cardiovascular and lung diseases. Methodology We cited more than 33 recent literature reviews that discussed the role played by adipocytokines in the pathogenesis of different diseases affecting different body systems. Conclusion More evidence is being discovered to date about the role played by adipocytokines in more diseases and extra research is needed to explore hidden roles played by adipokine imbalance on disease pathogenesis.

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脂肪细胞因子：它们是万有理论吗？

摘要 引言脂肪组织分泌多种生物活性肽/蛋白质、免疫分子和炎症介质，被称为脂肪因子或脂肪细胞因子。脂肪因子在维持能量稳态、食欲、葡萄糖和脂质代谢、胰岛素敏感性、血管生成、免疫和炎症中发挥重要作用。来自世界各地的大量研究证明，脂肪细胞因子参与了影响几乎所有身体系统的疾病的发病机制，这提出了一个问题：我们是否可以总是将脂肪细胞因子归咎于可能侵袭身体的每种疾病的触发因素。目的 我们的综述针对脂肪细胞因子在影响不同身体系统的不同疾病的发病机制中所发挥的作用，包括糖尿病、肾脏疾病、妇科疾病、风湿性疾病、癌症、阿尔茨海默氏症、抑郁症、肌肉疾病、肝脏疾病、心血管和肺部疾病。方法 我们引用了超过 33 篇最近的文献综述，讨论了脂肪细胞因子在影响不同身体系统的不同疾病的发病机制中所发挥的作用。结论 迄今为止，越来越多的证据表明脂肪细胞因子在更多疾病中发挥的作用，需要更多的研究来探索脂肪细胞因子失衡在疾病发病机制中所发挥的隐藏作用。