A facilitated-transport enantio-separation mechanism was proposed in this study and verified with an enantio-selective thin film composite membrane. The polysulfone membrane substrate was first fabricated at the optimized conditions, and the chiral selector α-CD was then incorporated into the selective layer by mixing with the MPD monomer for interfacial polymerization. Racemic tryptophan was employed as the model selectant, and inversed enantio-selectivities, 1.55 and 0.6 were observed from two different operation mode driven by concentration gradient and pressure gradient, respectively. The facilitated-transport separation mechanism was demonstrated by the concentration driven mode. The effects of other influencing factors including racemic feed concentration, α-CD concentration and pressure were also investigated.

在这项研究中提出了一种促进传输的对映体分离机理，并通过对映体选择性薄膜复合膜进行了验证。首先在最佳条件下制备聚砜膜基材，然后通过与MPD单体混合将手性选择剂α-CD掺入选择层中进行界面聚合。外消旋色氨酸作为模型选择剂，在浓度梯度和压力梯度驱动的两种不同操作模式下，对映体选择性分别为1.55和0.6。通过浓度驱动模式证明了促进运输分离的机理。还研究了外消旋饲料浓度，α-CD浓度和压力等其他影响因素的影响。