In heavy-ion therapy, the stopping position of primary ions in tumours needs to be monitored for effective treatment and to prevent overdose exposure to normal tissues. Positron-emitting ion beams, such as 11 C and 15 O, have been suggested for range verification in heavy-ion therapy using in-beam positron emission tomography (PET) imaging, which offers the capability of visualizing the ion stopping position with a high signal-to-noise ratio. We have previously demonstrated the feasibility of in-beam PET imaging for the range verification of 11 C and 15 O ion beams and observed a slight shift between the beam stopping position and the dose peak position in simulations, depending on the initial beam energy spread. In this study, we focused on the experimental confirmation of the shift between the Bragg peak position and the position of the maximum detected positron-emitting fragments via a PET system for positron-emitting ion beams of ...

中文翻译：

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动量接受对使用束内 PET 对 11C 和 15O 离子束进行范围监测的影响。

在重离子治疗中，需要监测原发离子在肿瘤中的停止位置以进行有效治疗并防止过量暴露于正常组织。正电子发射离子束，例如 11 C 和 15 O，已被建议用于使用束内正电子发射断层扫描 (PET) 成像的重离子治疗中的范围验证，它提供了以高可视化离子停止位置的能力信噪比。我们之前已经证明了束内 PET 成像用于 11 C 和 15 O 离子束范围验证的可行性，并观察到束停止位置和模拟中剂量峰值位置之间的轻微偏移，具体取决于初始束能量扩散。在这项研究中，