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Ethnobotanical study and phytochemical profiling of Heptapleurum hypoleucum leaf extract and evaluation of its antimicrobial activities against diarrhea-causing bacteria.
Journal of Genetic Engineering and Biotechnology ( IF 3.6 ) Pub Date : 2020-06-15 , DOI: 10.1186/s43141-020-00030-0
S M Rakib-Uz-Zaman 1 , Asif Iqbal 1 , Sadrina Afrin Mowna 1 , Mst Gitika Khanom 2 , Mohammad Mastak Al Amin 1 , Kashmery Khan 1
Affiliation  

Due to the development of superbugs as a result of unprescribed and frequent use of antibiotics in recent years, an alternate form of medicine had to be introduced. In light of this global threat, researchers all over the world have been gravitating towards herbal medicines. In order to find out new ways of saving the planet using medicinal plants, ethnobotanical studies must be carried out. Concerning this, an ethnobotanical study has been done in this paper to identify potential medicinal plants in Rangamati, Bangladesh. For the ethnobotanical survey, randomized 104 people were interviewed and 62 different plant species were found to treat 19 different kinds of diseases and 84% of people reported to be completely recovered. Furthermore, among the 19 diseases found, the majority of them were common cold, abdominal pain or gastric, diarrhea, and dysentery. From the 62 different plant species, Heptapleurum hypoleucum, used for the treatment of diarrhea, was selected for conducting further studies due to its heavy use as reported by the tribal people. In this study, the aqueous, ethanol, and methanol extracts of Heptapleurum hypoleucum were subjected to microbial susceptibility assays using the agar well diffusion method. The test microorganisms were Salmonella typhi, Streptococcus pneumoniae, Staphylococcus aureus, Shigella flexneri, and Escherichia coli. Among these, the most susceptible organisms were Staphylococcus aureus (21 mm) and Salmonella typhi (19 mm) in the ethanolic extract. Also, the methanolic extract showed an inhibition zone of 13 mm against E. coli, which was more than that of the antibiotic’s (11 mm). Phytochemical screening of the plant revealed that it contains alkaloids, phenols, steroids, and flavonoids, but lacks saponins and tannins. To combat the rising threat of antibiotic resistance, ethnoscience needs to be consolidated with modern biotechnological techniques to make the most use of the vast amount of natural resources. The findings of this study indicate that Heptapleurum hypoleucum, an ethnobotanical medicinal plant, has shown comparable antimicrobial activity with commercial antibiotics against several diarrhea-causing pathogens and also contains several medically important phytochemicals.

中文翻译:

幽门螺杆菌叶提取物的民族植物学研究和植物化学分析及其对引起腹泻的细菌的抗菌活性评估。

由于近年来由于无处方和频繁使用抗生素而导致超级细菌的发展,必须引入另一种药物形式。鉴于这种全球威胁,全世界的研究人员都将注意力转向了草药。为了找到使用药用植物拯救地球的新方法,必须进行民族植物学研究。对此,本文进行了一项民族植物学研究,以确定孟加拉国兰加马蒂的潜在药用植物。在人类植物学调查中,随机采访了104人,发现62种不同的植物可以治疗19种疾病,据报道84%的人已完全康复。此外,在发现的19种疾病中,大多数是普通感冒,腹痛或胃,腹泻,和痢疾。由于部落人民的报道,从62种不同的植物中,选择了用于治疗腹泻的次庚酸克鲁维酵母进行进一步的研究。在这项研究中,使用琼脂井扩散法对Heptapleurum hypoleucum的水提取物,乙醇提取物和甲醇提取物进行了微生物敏感性分析。测试的微生物是伤寒沙门氏菌,肺炎链球菌,金黄色葡萄球菌,弗氏志贺氏菌和大肠杆菌。其中,最易感的生物是乙醇提取物中的金黄色葡萄球菌(21毫米)和伤寒沙门氏菌(19毫米)。此外,甲醇提取物对大肠杆菌的抑制作用区域为13 mm,大于抗生素的抑制作用区域(11 mm)。植物的植物化学筛选显示,该植物含有生物碱,酚,类固醇和类黄酮,但缺少皂苷和单宁酸。为了应对日益增长的抗生素耐药性威胁,民族学需要与现代生物技术相结合,以充分利用大量自然资源。这项研究的结果表明,民族植物药hypoleuleucum,已显示出与商业抗生素具有可比性的对几种引起腹泻的病原体的抗菌活性,并且还含有几种医学上重要的植物化学物质。民族科学需要与现代生物技术相结合,以充分利用大量自然资源。这项研究的发现表明,民族植物药用植物七叶菌(Heptapleurum hypoleucum)已显示出与商业抗生素相当的抗微生物活性,可抗多种引起腹泻的病原体,并且还含有几种医学上重要的植物化学物质。民族科学需要与现代生物技术相结合,以充分利用大量自然资源。这项研究的发现表明,民族植物药用植物七叶菌(Heptapleurum hypoleucum)已显示出与商业抗生素相当的抗微生物活性,可抗多种引起腹泻的病原体,并且还含有几种医学上重要的植物化学物质。
更新日期:2020-06-15
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