Engineered macroporous hydrogel scaffolds via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration.,Journal of Materials Chemistry B

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Engineered macroporous hydrogel scaffolds via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-06-15 , DOI: 10.1039/d0tb00901f
Haotian Pan ₁ , Huichang Gao , Qingtao Li , Zefeng Lin , Qi Feng , Chenxi Yu , Xiaohua Zhang , Hua Dong , Dafu Chen , Xiaodong Cao

Affiliation

Hydrogels are appealing biomaterials for regenerative medicine since biomimetic modifications of their polymeric network can provide unique physical properties and emulate the native extracellular matrix (ECM). Meanwhile, therapeutic metal ions, such as magnesium ions (Mg²⁺), not only regulate cellular behaviours but also stimulate local bone formation and healing. However, the absence of a meaningful macroporous structure and the uncompromising mechanical strength are still challenges. Herein, we designed a macroporous composite hydrogel based on mild and fast thiol–ene click reactions. The Pickering emulsion method was adopted to form a macroporous structure and introduce MgO nanoparticles (NPs). The results show that the composite hydrogel possesses good mechanical strength and an evenly distributed macroporous structure. MgO NPs stabilized at the oil/water interface not only function as effective emulsion stabilizers, but also enhance the mechanical properties of hydrogels and mediate the sustained release of Mg²⁺. In vitro cell experiments demonstrated that the composite hydrogel displays good biocompatibility. More importantly, the release of Mg²⁺ ions from hydrogels can effectively promote the osteogenic differentiation of BMSCs. Furthermore, an in vivo study showed that macroporous hydrogels can provide a good extracellular matrix microenvironment for in situ osteogenesis and accelerate bone tissue regeneration.

中文翻译：

工程化的大孔水凝胶支架通过由MgO纳米颗粒稳定的拾取器乳剂促进骨再生。

水凝胶是用于再生医学的有吸引力的生物材料，因为对其聚合物网络进行仿生修饰可以提供独特的物理特性并模仿天然的细胞外基质（ECM）。同时，治疗性金属离子，例如镁离子（Mg ²⁺），不仅可以调节细胞行为，还可以刺激局部骨骼的形成和愈合。然而，缺乏有意义的大孔结构和不折不扣的机械强度仍然是挑战。本文中，我们基于轻度和快速硫醇-烯点击反应设计了大孔复合水凝胶。采用Pickering乳液法形成大孔结构并引入MgO纳米颗粒（NPs）。结果表明，复合水凝胶具有良好的机械强度和均匀分布的大孔结构。稳定在油/水界面的MgO NPs不仅可以作为有效的乳液稳定剂，还可以增强水凝胶的机械性能并介导Mg ²⁺的持续释放。体外细胞实验证明复合水凝胶显示出良好的生物相容性。更重要的是，从水凝胶中释放Mg ²⁺离子可以有效促进BMSCs的成骨分化。此外，一项体内研究表明，大孔水凝胶可为原位成骨提供良好的细胞外基质微环境，并促进骨组织再生。

更新日期：2020-07-22

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