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Nanotechnology for angiogenesis: opportunities and challenges.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-06-15 , DOI: 10.1039/c8cs01021h Saeid Kargozar 1 , Francesco Baino , Sepideh Hamzehlou , Michael R Hamblin , Masoud Mozafari
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-06-15 , DOI: 10.1039/c8cs01021h Saeid Kargozar 1 , Francesco Baino , Sepideh Hamzehlou , Michael R Hamblin , Masoud Mozafari
Affiliation
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Angiogenesis plays a critical role within the human body, from the early stages of life (i.e., embryonic development) to life-threatening diseases (e.g., cancer, heart attack, stroke, wound healing). Many pharmaceutical companies have expended huge efforts on both stimulation and inhibition of angiogenesis. During the last decade, the nanotechnology revolution has made a great impact in medicine, and regulatory approvals are starting to be achieved for nanomedicines to treat a wide range of diseases. Angiogenesis therapies involve the inhibition of angiogenesis in oncology and ophthalmology, and stimulation of angiogenesis in wound healing and tissue engineering. This review aims to summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail. Theranostic and imaging approaches can be facilitated by nanoparticles. Many preparations have been reported to have a bimodal effect where they stimulate angiogenesis at low dose and inhibit it at higher doses.
中文翻译：
血管生成纳米技术：机遇与挑战。
血管生成在人体中发挥着关键作用，从生命的早期阶段(即，胚胎发育)到危及生命的疾病(例如，癌症、心脏病、中风、伤口愈合)。许多制药公司在刺激和抑制血管生成方面投入了大量精力。在过去的十年中，纳米技术革命对医学产生了巨大影响，用于治疗多种疾病的纳米药物开始获得监管部门的批准。血管生成疗法涉及肿瘤学和眼科中血管生成的抑制，以及伤口愈合和组织工程中血管生成的刺激。本综述旨在总结在血管生成广泛领域中探索的基于纳米技术的策略。详细介绍了脂基、碳基和聚合物纳米颗粒，以及各种无机和金属纳米颗粒。纳米粒子可以促进治疗诊断和成像方法。据报道，许多制剂具有双峰效应，低剂量时刺激血管生成，高剂量时抑制血管生成。
更新日期：2020-07-21
中文翻译：
血管生成纳米技术：机遇与挑战。
血管生成在人体中发挥着关键作用，从生命的早期阶段(即，胚胎发育)到危及生命的疾病(例如，癌症、心脏病、中风、伤口愈合)。许多制药公司在刺激和抑制血管生成方面投入了大量精力。在过去的十年中，纳米技术革命对医学产生了巨大影响，用于治疗多种疾病的纳米药物开始获得监管部门的批准。血管生成疗法涉及肿瘤学和眼科中血管生成的抑制，以及伤口愈合和组织工程中血管生成的刺激。本综述旨在总结在血管生成广泛领域中探索的基于纳米技术的策略。详细介绍了脂基、碳基和聚合物纳米颗粒，以及各种无机和金属纳米颗粒。纳米粒子可以促进治疗诊断和成像方法。据报道，许多制剂具有双峰效应，低剂量时刺激血管生成，高剂量时抑制血管生成。
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