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Mitochondrial-targeted deep-red fluorescent probe for ATP and its application in living cells and zebrafish.
Analytical Methods ( IF 2.7 ) Pub Date : 2020-06-15 , DOI: 10.1039/d0ay00942c Wentao Peng 1 , Mingxing Hu 2 , Jian Zhang 3
Analytical Methods ( IF 2.7 ) Pub Date : 2020-06-15 , DOI: 10.1039/d0ay00942c Wentao Peng 1 , Mingxing Hu 2 , Jian Zhang 3
Affiliation
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A novel mitochondrial-targeted deep-red fluorescence ATP probe, NIR-A, is reported. The probe showed a fast, selective, and reversible response for ATP with a significant turn-on fluorescence signal at 663 nm with a large Stokes shift of 81 nm. Additionally, the introduction of TPP enabled TPP-endowed NIR-A to be enriched predominantly in the mitochondria. NIR-A was successfully applied to monitor ATP fluctuation in Ramos cells and zebrafish in real-time with good biocompatibility.
中文翻译：
线粒体靶向的深红色ATP荧光探针及其在活细胞和斑马鱼中的应用。
报道了一种新型的线粒体靶向深红色荧光ATP探针NIR-A。该探针显示出对ATP的快速，选择性和可逆的响应，在663 nm处具有明显的开启荧光信号，并且斯托克斯位移为81 nm。此外，TPP的引入使TPP赋予的NIR-A主要在线粒体中富集。NIR-A已成功应用于具有良好生物相容性的实时监测Ramos细胞和斑马鱼中ATP的波动。
更新日期：2020-07-09
中文翻译：
线粒体靶向的深红色ATP荧光探针及其在活细胞和斑马鱼中的应用。
报道了一种新型的线粒体靶向深红色荧光ATP探针NIR-A。该探针显示出对ATP的快速，选择性和可逆的响应，在663 nm处具有明显的开启荧光信号，并且斯托克斯位移为81 nm。此外，TPP的引入使TPP赋予的NIR-A主要在线粒体中富集。NIR-A已成功应用于具有良好生物相容性的实时监测Ramos细胞和斑马鱼中ATP的波动。
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