Background/Purpose: Effective symptom assessment and management for children with advanced cancer undergoing hematopoietic stem cell transplantation (HSCT) is critical to minimize suffering. The purpose of this subanalysis was to compare feasibility of electronic data collection data and symptom prevalence, frequency, severity, and distress from children with advanced cancer undergoing HSCT with a non-HSCT cohort. Method: An abbreviated Pediatric Quality of Life and Evaluation of Symptoms Technology Memorial Symptom Assessment Scale was electronically administered every 2 weeks to children with advanced cancer. A subanalysis was conducted for the cohort of children who received autologous or allogeneic HSCT. Results: Forty-six participants completed 563 symptom assessments during the study. However, 11 of these 46 children received HSCT and completed 201 symptom assessments. The median age in the HSCT cohort was 12.7 years, 73% were female, and most children had a hematologic (45%) or solid tumor (45%) malignancy. Pain (35%), nausea (30%), sleeping difficulty (29%), and fatigue (22%) were the most commonly reported symptoms in children receiving HSCT. Children in the HSCT cohort had similar total, subscale, and individual symptom scores compared with children who did not receive HSCT. Certain domains of gastrointestinal symptoms (nausea, lack of appetite, and diarrhea) were higher for children receiving HSCT compared with children with advanced cancer not receiving HSCT (p < .05). Conclusion: Elicitation of patient-reported symptom experiences using electronic methods improves nurses’ understanding of the symptom experience for children with advanced cancer undergoing HSCT and may promote timely assessment and treatment of distressing symptoms.

中文翻译：

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接受造血干细胞移植的晚期癌症儿童和青少年的电子症状评估

背景/目的：对接受造血干细胞移植 (HSCT) 的晚期癌症儿童进行有效的症状评估和管理对于尽量减少痛苦至关重要。本次分析的目的是比较电子数据收集数据的可行性，以及接受 HSCT 的晚期癌症儿童与非 HSCT 队列的症状患病率、频率、严重程度和痛苦。方法：每两周对患有晚期癌症的儿童进行一次简短的儿科生活质量和症状评估技术纪念症状评估量表。对接受自体或异基因 HSCT 的儿童队列进行了亚组分析。结果：46 名参与者在研究期间完成了 563 项症状评估。然而，这 46 名儿童中有 11 名接受了 HSCT 并完成了 201 项症状评估。HSCT 队列的中位年龄为 12.7 岁，73% 为女性，大多数儿童患有血液学 (45%) 或实体瘤 (45%) 恶性肿瘤。疼痛 (35%)、恶心 (30%)、睡眠困难 (29%) 和疲劳 (22%) 是接受 HSCT 的儿童最常见的症状。与未接受 HSCT 的儿童相比，HSCT 队列中的儿童具有相似的总分、分量表和个体症状评分。与未接受 HSCT 的晚期癌症儿童相比，接受 HSCT 的儿童在胃肠道症状的某些方面（恶心、食欲不振和腹泻）更高（p < .05）。结论：